S&S On Biotech
Conversations on the science and business of Biotechnology with Andy Smith and Cormac Sheridan.
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Podcasting since 2023 • 31 episodes
S&S On Biotech
Latest Episodes
3.9 The slow rise of TCR-T therapy
When the first chimeric antigen receptor T-cell (CAR-T) therapy was approved in 2017, there was a general expectation that T-cell receptor T-cell (TCR-T) therapies would follow shortly afterwards and would greatly expand the range of addressabl...
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36:07
3.8 Innovation in Myasthenia Gravis: The leap from poison arrows to targeted therapy
In 1934, Mary Walker, a pioneering Scottish physician, successfully, albeit transiently, treated a myasthenia gravis patient with physostigmine, a traditional remedy for treating poisoning with curare. She had noticed that the signs and symptom...
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Season 3
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Episode 8
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29:22
3.7 Melanoma: At the frontier of cancer immunotherapy
Melanoma has been at the very centre of the cancer immunotherapy revolution over the past decade and a half. The CTLA-4 inhibitor Yervoy (ipilimumab), which gained approval in 2011, was the first agent to demonstrate a survival improvement in a...
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31:32
3.6 Brain Cancer – The unkindest cancer of all?
This is a sobering episode that traces the history of the treatment of brain cancer – principally malignant glioma, since it is the most common diagnosis in a thankfully rare oncology indication – and how, unlike many of the indications we have...
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Season 3
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Episode 6
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29:42
3.5 Eyes on the prize: Developing therapies for ophthalmic disease
Ophthalmology has long been a fruitful area for biotechnology innovation. In highly prevalent conditions associated with ageing, such as age-related macular degeneration, or with chronic disease, such as diabetic macular oedema, vascula...
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Season 3
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Episode 5
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37:57