S&S On Biotech
Conversations on the science and business of Biotechnology with Andy Smith and Cormac Sheridan.
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Episodes
31 episodes
3.9 The slow rise of TCR-T therapy
When the first chimeric antigen receptor T-cell (CAR-T) therapy was approved in 2017, there was a general expectation that T-cell receptor T-cell (TCR-T) therapies would follow shortly afterwards and would greatly expand the range of addressabl...
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36:07
3.8 Innovation in Myasthenia Gravis: The leap from poison arrows to targeted therapy
In 1934, Mary Walker, a pioneering Scottish physician, successfully, albeit transiently, treated a myasthenia gravis patient with physostigmine, a traditional remedy for treating poisoning with curare. She had noticed that the signs and symptom...
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Season 3
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Episode 8
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29:22
3.7 Melanoma: At the frontier of cancer immunotherapy
Melanoma has been at the very centre of the cancer immunotherapy revolution over the past decade and a half. The CTLA-4 inhibitor Yervoy (ipilimumab), which gained approval in 2011, was the first agent to demonstrate a survival improvement in a...
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31:32
3.6 Brain Cancer – The unkindest cancer of all?
This is a sobering episode that traces the history of the treatment of brain cancer – principally malignant glioma, since it is the most common diagnosis in a thankfully rare oncology indication – and how, unlike many of the indications we have...
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Season 3
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Episode 6
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29:42
3.5 Eyes on the prize: Developing therapies for ophthalmic disease
Ophthalmology has long been a fruitful area for biotechnology innovation. In highly prevalent conditions associated with ageing, such as age-related macular degeneration, or with chronic disease, such as diabetic macular oedema, vascula...
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Season 3
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Episode 5
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37:57
3.4 Allergy’s innovation gap
For all the extraordinary progress we have seen in basic biological research and in the development of advanced therapies, allergy is an area that seems to be stuck and badly in need of innovation. For some, an allergy may be little worse than ...
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Season 3
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Episode 4
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24:43
3.3 Where have all the PROTACs gone?
A couple of years ago, PROTACs were ubiquitous. Start-ups were devising increasingly clever ways of making them, while large pharma companies were queuing up to tap into their expertise and their development programs. Proteolysis-targeting chim...
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Season 3
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Episode 3
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27:14
3.2 Kidney Disease: a really big problem that’s getting bigger
Over 10% of the world’s population – or 850 million people – are estimated to have kidney disease, and the problem is growing rapidly. The vast majority lives in low-income or low-and-middle-income countries, and, without access to primary heal...
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Season 3
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Episode 2
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28:09
3.1 Death and its discontents – or extending human longevity
Human longevity is a precious thing. Some people receive a tragically short amount of it. Others who have it in abundance want even more of it – and a reasonable chunk of the biopharmaceutical industry has organised itself around the goal of de...
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Season 3
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Episode 1
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25:16
2.12. The unfulfilled promise of cancer vaccines
Therapeutic cancer vaccines have had a long and chequered history. The BCG (Bacillus Calmette-Guérin) vaccine, originally developed to protect against tuberculosis in the 1920s, was adopted back in the 1970s as treatment for bladder cancer. Whe...
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Season 2
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Episode 12
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28:53
2.11. The healing game: Biotech in recovery
The flow of money is a constant preoccupation of the biotechnology sector, because without it nothing gets done. So, whether the markets are up or down, and whether investors are buying or selling is important, even if it is secondary to the ac...
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Season 2
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Episode 11
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32:54
2.10 Relyvrio’s setback in ALS is a clinical and a regulatory failure
The failure of Relyvrio in a post-approval phase 3 study in amyotrophic lateral sclerosis (ALS) means its days as a commercial drug are probably numbered. It initially gained approval in Canada in June 2022 (where it is, confusingly, known as A...
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Season 2
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Episode 10
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27:39
2.9. Ironwood’s woes or why a stock craters after a ‘successful’ phase 3 trial
A 40% share price drop after an investigational drug hits the primary endpoint of a phase 3 trial is not typical. But that’s what happened to Ironwood Pharmaceuticals when it reported data from a trial of apraglutide in patients with intestinal...
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Season 2
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Episode 9
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29:42
2.8. Alnylam’s big bet in amyloidosis
By late June or early July we’ll know whether Alnylam’s decision to alter the design of its phase 3 ‘Healios B’ study of Amvuttra (vutrisiran) in transthyretin amyloidosis with cardiomyopathy (ATTR-CM) was a good one. The short-interfering RNA ...
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Season 2
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Episode 8
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27:43
2.7. ‘MetaMorphosys’ or how a big pivot paid off (kind of)
Novartis’s recent €2.7 billion ($2.9 billion) offer for Morphosys is the very stuff of biotechnology. The medium-sized deal adds two clinical-stage cancer drug candidates to its pipeline. Both operate through epigenetic mechanisms ...
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Season 2
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Episode 7
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23:50
2.6. Hereditary angioedema: Biotech innovation in action
Hereditary angioedema (HAE), arguably, represents an ideal case of the Orphan Drug rules in action. Because of the incentives on offer, a mini-cluster of firms has, over the past fifteen years, developed a well-stocked cabinet of therapies for ...
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Season 2
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Episode 6
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28:56
2.5 NASH. What’s in a name? Mash and Nash both spell liver disease
Non-alcoholic steatohepatitis (NASH) and its precursor non-alcoholic fatty liver disease (NAFLD) have recently been redesignated as MASH and MASLD – metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic...
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Season 2
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Episode 5
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28:42
2.4 When is a deal not a deal. Sanofi makes a big bet in AATD
Sanofi’s partial acquisition of Inhibrx recalls earlier transactions, such as Pfizer’s acquisition of BioHaven or, to go back even further, Johnson & Johnson’s acquisition of Actelion, in which assets deemed surplus to the acquirer’s needs ...
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Season 2
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Episode 4
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23:48
2.3 Radiopharmaceuticals space heats up as BMS and Lilly join the fray
The use of radiation in medicine began with the work of the great pioneers Marie Curie, her husband Pierre, and Henri Becquerel. In the 1940s, Samuel Hertz, Samuel Seidlin, and William Beierwaltes established radioactive iodine (I-131) as a tre...
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Season 2
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Episode 3
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25:39
2.2 Recent Biotech Acquisitions. Done Already, or More to Come?
The annual JP Morgan Healthcare Conference, held in San Francisco every January, marks the start of the biotech industry’s new year. It’s the time when biotechnology companies of all shapes and sizes set out their stall for the year ahead, hopi...
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Season 2
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Episode 2
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25:32
2.1 The FTC vs. Sanofi. Stifling innovation or smashing monopolies?
In its own words, the U.S. Federal Trade Commission’s opposition to a licensing deal between Sanofi and the biotechnology firm Maze Therapeutics, “is a case about a monopolist seeking to eliminate a nascent threat to its monopoly”.
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Season 2
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Episode 1
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26:54
1.10 Have ADCs peaked?
Have antibody-drug conjugates peaked—or is there more innovation to come?Antibody-drug conjugates (ADCs) are complex products, and it has taken the field some time to iron out some of the difficulties that hampered their initial developm...
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Season 1
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Episode 10
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29:13
1.9 Historic approval of CRISPR-Cas9 gene editing therapy a game changer – for some
The UK approval of the CRISPR-Cas9 gene editing therapy Casgevy (exagamglogene autotemcel or ‘exa-cel’) for treating the inherited blood disorders sickle cell disease (SCD) or transfusion-dependent b-thalassemia is an historic scientific and cl...
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Season 1
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Episode 9
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25:27
1.8 Are CAR-Ts stuck?
When they first emerged, chimeric antigen receptor T-cell (CAR-T) therapies seemed like the stuff of science fiction. The basic idea of reprogramming T-cells is decades old. It involves isolating a patient’s T-cells, genetically modifying them ...
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Season 1
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Episode 8
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31:06
1.7 Biosimilars. Have they delivered?
When I was a global product manager in big pharma, my US counterpart mentioned to me one day that “we do generics properly in the US, not like you do in Europe.” He meant that when a small molecule went generic in the US, and the 180-day first-...
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Season 1
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Episode 7
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23:45